What if... MJ was the one bitten by the radioactive spider?
Then It Would Still Be Spider-Woman But Just Like Boyfriend Peter She Too Would Suffer The Loss Of A Family Member, This Time Is Her Aunt.
Having her not stopping the burglar that shot Ben when she could, could just as well work as a guilt-trip backstory moment when she change from just using her Powers for fun and profit to actually becoming a hero. Since she probably see the Parker as the good stable family she herself lacked and being behind the destruction of that would hit her hard.
Alternative having her losing her aunt could lead to her being taken in by the Parker’s leading to Peter being her science-sidekick
where did you made them?